THE LOCALIZATION OF HEPARIN-LIKE BLOOD ANTICOAGULANT SUBSTANCES IN THE TISSUES OF SPISULA SOLIDISSIMA
Open Access
- 1 February 1954
- journal article
- research article
- Published by University of Chicago Press in The Biological Bulletin
- Vol. 106 (1), 129-138
- https://doi.org/10.2307/1538785
Abstract
A blood anticoagulant material equal in potency to heparin was obtained from the surf clam, Spisula (Mactra) solidissima. by means of a heparin extraction procedure. The amt. of anticoagulant in various tissues of this clam was compared with the pattern of metachromatic staining in tissue sections. It was concluded that the anticoagulant is derived in part from a mucous secretion peculiar to the palps, gills and inner mantle surface and in part from an intercellular connective tissue substance found predominantly in the mantle structure. It was postulated that this connective tissue substance may be involved in calcification processes. The eggs of Spisula were also found to contain anticoagulant material thought to be derived mainly from the jelly coat but in part from the cortex and nucleolus.This publication has 6 references indexed in Scilit:
- Heparin-Like Anticoagulants from MolluscaExperimental Biology and Medicine, 1953
- THE EFFECT OF DYES ON THE CALCIFICATION OF HYPERTROPHIC RACHITIC CARTILAGE IN VITROThe Journal of Experimental Medicine, 1952
- CALCIFICATION IN MOLLUSCS. III. INTAKE AND DEPOSITION OF Ca45 AND P32 IN RELATION TO SHELL FORMATIONThe Biological Bulletin, 1952
- Differential staining of various polysaccharides in sea urchin eggsExperimental Cell Research, 1950
- The Effect of Heparin on Cell Division.Experimental Biology and Medicine, 1949
- A simple method for the purification of heparinBiochimica et Biophysica Acta, 1948