A new type of silyl protecting groups in nucleoside chemistry

Abstract
A new type of silyl protecting group was designed and a reagent for its introduction was obtained. This reagent, 1,3--dihalo-1,1,3,3-tetraalkyldisiloxane, allows simultaneous protection of 3′-OH and 5′-OH groups of nucleoside in high yield. The properties of the new protecting group were studied and some aspects of its applications are presented.