Hydroxypyruvate as a gluconeogenic substrate in rat hepatocytes
- 1 January 1975
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 146 (1), 277-279
- https://doi.org/10.1042/bj1460277
Abstract
At concentrations of 2mM and above hydroxypyruvate produced no glucose with isolated rat liver cells, although it was rapidly utilized. At a lower concentration of hydroxypyruvate or in the presence of substrates which generate reducing equivalents (ethanol or butyrate), appreciable amounts of glucose were formed from hydroxypyruvate. A possible explanation for this phenomenon is discussed.Keywords
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