Nocardicin a, a new monocyclic .BETA.-lactam antibiotic. I. Discovery, isolation and characterization.

Abstract

Nocardicin A is a new monocyclic .beta.-lactam antibiotic obtained from the fermentation broth of a strain of actinomycetes. The producing organism, strain WS 1571, was identified as Nocardia uniformis ssp. tsuyamanensis ATCC 21806. The antibiotic, obtained as colorless crystals, exhibits moderate in vitro antibacterial activity against a broad-spectrum of gram-negative bacteria including Proteus and Pseudomonas. It has low toxicity in laboratory animals [mice and rats].