THE PREDICTION OF ACUTE REJECTION IN HUMAN RENAL TRANSPLANTATION USING THE LEUCOCYTE MIGRATION TEST

Abstract

SUMMARY Using serial leucocyte migration tests with donor-specific antigens, 12 recipients of cadaver renal homografts have been followed for the first 3 months after operation. In 8 out of 10 rejection episodes, inhibition of migration was observed 24 hr to 5 days before the diagnosis of rejection was made on clinical and biochemical grounds. There have been no false positive results in the study. It is concluded that the test is of value in predicting acute rejection after renal transplantation.