BACKWARD WALKING AND CIRCLING: BEHAVIOURAL RESPONSES INDUCED BY DRUG TREATMENTS WHICH CAUSE SIMULTANEOUS RELEASE OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE
Open Access
- 1 August 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 66 (4), 573-579
- https://doi.org/10.1111/j.1476-5381.1979.tb13696.x
Abstract
1 The roles of catecholamine and 5-hydroxytryptamine (5-HT) release in mediating backward walking and circling were studied in rats. 2 These behaviours occurred in animals given 15mg/kg intraperitoneally of (+)-amphetamine (which predominantly releases catecholamines) or either p-chloroamphetamine or fenfluramine (which predominantly release 5-HT). They also occurred when smaller doses of (+)-amphetamine (5mg/kg) and either p-chloroamphetamine (2–5 mg/kg) or fenfluramine (5 mg/kg) were given together. 3 Characteristic dopamine-dependent behaviours (rearing, licking, gnawing) resulting from (+)-amphetamine injection were greatly reduced by p-chloroamphetamine or fenfluramine. 4 Characteristic 5-HT-dependent behaviours (wet dog shake, hind limb abduction) resulting from injection of either p-chloroamphetamine or fenfluramine were unaffected by (+)-amphetamine. 5 Fragmentary backward walking and circling resulting from levallorphan injection (50 mg/kg s.c.) were decreased by (+)-amphetamine at low dosage. 6 Results in general strengthen previous evidence that backward walking and circling are mediated by simultaneous dopamine and 5-HT release. 7 The possible relevance of the above findings to hallucinogenic activity, amphetamine psychosis, schizophrenia and abnormal movements due to l-DOPA treatment is discussed.Keywords
This publication has 33 references indexed in Scilit:
- Serotonergic involvement in behavioural responses to amphetamine at high dosageNeuropharmacology, 1979
- Acute toxicity and gross behavioral effects of amphetamine, four methoxyamphetamines, and mescaline in rodents, dogs, and monkeysToxicology and Applied Pharmacology, 1978
- Serotonergic component of neuroleptic receptorsNature, 1978
- Action of some fluorinated amphetamine‐like compounds on the synaptosomal uptake of neurotransmittersJournal of Neurochemistry, 1976
- Is there a catecholamine-serotonin interaction in the control of locomotor activity?Neuropharmacology, 1975
- LSD and dopamine-sensitive adenylate-cyclase in various rat brain areasBrain Research, 1975
- Serotonergic inhibition of catecholamine-induced behavioral arousalBrain Research, 1973
- L-Dopa-Induced Release of Cerebral MonoaminesScience, 1970
- Behavioural Effects of some Morphine Antagonists and Hallucinogens in the RatNature, 1968
- Some New Behaviour-disrupting Amphetamines and their SignificanceNature, 1967