Antitumor 1-(X-aryl)-3,3-dialkyltriazenes. 1. Quantitative structure-activity relationships vs L1210 leukemia in mice

Abstract

Quantitative structure-activity relationships (QSAR) were formulated for phenyl-, pyrazolyl- and imidazolyltriazenes acting against L1210 leukemia in mice. All 3 sets of congeners had the same ideal lipophilicity (log Po .apprxeq. 1). Electron-releasing substituents increase potency; ortho substitution decreases activity. The synthesis of a number of new triazenes and some of their partition coefficients were reported.