Opiates Stimulate Low Km GTPase in Brain
- 1 October 1984
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 43 (4), 1132-1135
- https://doi.org/10.1111/j.1471-4159.1984.tb12853.x
Abstract
Low Km GTp hydrolysis in rat brain is stimulated in a concentration-dependent manner by the opiate alkaloid etorphine, and by the opioid peptide D-Ala2-leucine-enkephalinamide. The opiate antagonist naloxone inhibits the maximal D-Ala2-leucine-enkephalinamide stimulation of the GTPase, also with concentration dependency. The magnitude of maximally stimulated, opioid-sensitive, GTP hydrolysis is differentially distributed across brain regions. Opioid-stimulated GTPase may represent 1 means of identifying a specific type of opioid receptor.Keywords
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