Cerebrospinal Fluid Peptide YY Immunoreactivity in Eating Disorders
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 19 (3), 121-124
- https://doi.org/10.1159/000118446
Abstract
Peptide YY (PYY), a recently discovered peptide, is a potent stimulant of eating behavior in rats. We developed a radioimmunoassay for PYY and measured cerebrospinal fluid (CSF) levels in subjects with anorexia nervosa, bulimia and matched normal controls. Bulimics who had abstained from bingeing for 30 days showed a dramatic increase in CSF PYY levels compared to normal values (p < 0.001) or their own values when actively bingeing (p < 0.01, paired t test). No differences were seen for anorexia nervosa. These results suggest that bulimic behavior may correct a central nervous system abnormality in PYY.This publication has 5 references indexed in Scilit:
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