Vasopressin gene is expressed at low levels in the hypothalamus of the Brattleboro rat.
- 1 September 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (17), 5296-5299
- https://doi.org/10.1073/pnas.81.17.5296
Abstract
The Brattleboro rat carries as a recessive trait the inability to synthesize hypothalamic vasopressin and its related neurophysin but is able to synthesize oxytocin and its neurophysin. Brattleboro rats homozygous for this trait have no immunologically detectable circulating vasopressin and manifest a complete syndrome of diabetes insipidus, which is corrected with vasopressin replacement therapy. Such a defect could be due to absence of the gene encoding vasopressin, the presence of an abnormal gene, or a variety of transcriptional or posttranscriptional abnormalities. The hypothalamus of the Brattleboro rat contains detectable, although markedly reduced, levels of an mRNA indistinguishable in size with and similar in sequence to authentic vasopressin mRNA. Corresponding levels of oxytocin mRNA were the same in Brattleboro and normal rat hypothalami. The Brattleboro rat expresses a vasopressin gene, but at a reduced level.This publication has 25 references indexed in Scilit:
- Molecular endocrinology: Vasopressin, tissue-specific defects and the Brattleboro ratNature, 1984
- Polymorphism near the rat prolactin gene caused by insertion of an Alu-like elementNature, 1983
- Specific transcription and RNA splicing defects in five cloned β-thalassaemia genesNature, 1983
- Deduced amino acid sequence from the bovine oxytocin–neurophysin I precursor cDNANature, 1983
- Gene conversion and polymorphism: Generation of mouse immunoglobulin γ2a chain alleles by differential gene conversion by γ2b chain geneCell, 1983
- Abnormal RNA processing due to the exon mutation of βE-globin geneNature, 1982
- Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin–neurophysin II precursorNature, 1982
- Synthesis, Transport, and Release of Posterior Pituitary HormonesScience, 1980
- [57] Sequencing end-labeled DNA with base-specific chemical cleavagesMethods in Enzymology, 1980
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979