The authors review the treatment of chromophobe adenomas at the Hospital of the University of Pennsylvania from 1950 through 1967. Only 6% of the early group received postoperative radiotherapy, whereas 46% of the later group were treated in this manner. In each period, one-third received irradiation alone. As in several other published series, the results of irradiation alone and planned postoperative radiation therapy were the same. Radiation therapy alone is recommended for the initial treatment of chromophobe adenoma except when rapid progressionof visual loss occurs.