Activity of 5-Episisomicin Compared with That of Other Aminoglycosides

Abstract

5-Episisomicin, a semisynthetic aminoglycoside, has been shown to inhibit many members of the Enterobacteriaceae, Pseudomonas aeruginosa , and Staphylococcus aureus . At a concentration of 3.1 μg/ml, more than 90% of Escherichia coli, Klebsiella pneumoniae, Enterobacter, Citrobacter , indole-positive Proteus , and Providencia were inhibited. 5-Episisomicin had activity against S. aureus, E. coli, Klebsiella, Enterobacter , and Citrobacter similar to gentamicin and netilmicin. It had activity similar to amikacin and netilmicin against many gentamicin-resistant bacteria. The activity of 5-episisomicin was greatest at an alkaline pH and in medium of low magnesium content. Synergy of 5-episisomicin and carbenicillin was found to occur most often against Pseudomonas .