THE EFFECT OF L-NOREPINEPHRINE ON CARDIAC OUTPUT IN THE ANESTHETIZED DOG DURING GRADED HEMORRHAGE 1

Abstract

In exptl. hemorrhagic hypotension in dogs, l-norepinephrine (0.75 [mu]/min./kg ) elicits significant increases of cardiac output and arterial pressure. Later in hemorrhage and after the development of irreversible shock, 1-norepinephrine effects no significant change of arterial pressure or cardiac output. During no stage of hemorrhagic hypotension did the drug elicit an increase of total peripheral resistance.