Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases
- 1 March 1978
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 57 (3), 201-215
- https://doi.org/10.1111/j.1600-0404.1978.tb05867.x
Abstract
The activities of 4 lysosomal acid hydrolases, .beta.-galactosidase [EC 3.2.1.23], .alpha.-mannosidase [EC 3.2.1.24] at pH 4.5 and 5.5, N-acetyl-.beta.-glucosaminidase [EC 3.2.1.30) and acid phosphatase [EC 3.1.3.2], were measured in serum and CSF from 179 patients with different neurological diseases and from 20 healthy controls. In patients with tumors, decreased activity of .beta.-galactosidase was found in both serum and CSF and in patients with multiple sclerosis and collagen diseases, decreased activities of .beta.-galactosidase and N-acetyl-.beta.-glucosaminidase were found in CSF fluid. The variations of enzyme activities were great between the individual patients even within these groups and analysis of lysosomal enzymes seems to have a very poor clinical value.This publication has 29 references indexed in Scilit:
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