Niemann-Pick Disease Experimental Model: Sphingomyelinase Reduction Induced by AY-9944
- 15 April 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4287), 317-319
- https://doi.org/10.1126/science.66749
Abstract
Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.Keywords
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