Formation and Metabolism of 3',5'-Diiodothyronine and 3,5-Diiodothyronine by Cultured Monkey Hepatocarcinoma Cells
- 1 March 1979
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 11 (03), 233-237
- https://doi.org/10.1055/s-0028-1092715
Abstract
Cultured monkey hepatocarcinoma cells were incubated with |3',5'-125I]diiodo-L-thyronine and with [3,5-125I]diiodo-L-thyronine. In both instances monodeiodination as well as sulfoconjugation took place. [3.-125I]iodothyronine and [3',5'-125I] diiodothyronine were identified as metabolites of [3'-5',-125I]-L-thyroxine in the cells, but neither [3-125I]-iodothyronine nor [3,5-125I] diiodothyronine was detected after incubation of the cells with [3,5-125I]-L-thyroxine. No products of diphenyl ether splitting were observed in the medium after incubation of the cells with either [3,5-125I] diiodo-L-thyronine or [3,5-125l]-L-thyroxine.Keywords
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