In Vivo Association Between Alcohol Intoxication, Aggression, and Serotonin Transporter Availability in Nonhuman Primates
- 1 August 1998
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 155 (8), 1023-1028
- https://doi.org/10.1176/ajp.155.8.1023
Abstract
OBJECTIVE: Studies on brain serotonin metabolism in human and nonhuman primates have indicated that dysfunction of serotonin transmission may play a role in the biological vulnerability to dependence on alcohol. Among young men, low sensitivity to alcohol intoxication predicts subsequent alcohol abuse and dependence. METHOD: The authors used single photon emission computed tomography and the radioligand [I123]β-CIT ([I123]methyl 3β-(4-iodophenyl) tropane-2-carboxylate) to measure the availability of serotonin transporters in 11 male rhesus monkeys, and the monkeys were genotyped for a functional polymorphism of the serotonin transporter gene. The 11 monkeys had experienced parental separation after birth; their behavior and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in CSF had been assessed regularly. RESULTS: In the 5-year-old monkeys, there was a significant negative correlation between β-CIT binding to serotonin transporters in the brainstem and 5-HIAA concentrations in CSF. Animals with greate...Keywords
This publication has 34 references indexed in Scilit:
- Early-Onset Alcoholics Have Lower Cerebrospinal Fluid 5-Hydroxyindoleacetic Acid Levels Than Late-Onset AlcoholicsArchives of General Psychiatry, 1996
- An 8-Year Follow-up of 450 Sons of Alcoholic and Control SubjectsArchives of General Psychiatry, 1996
- The Structure of the Genetic and Environmental Risk Factors for Six Major Psychiatric Disorders in WomenArchives of General Psychiatry, 1995
- In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiologyHuman Brain Mapping, 1995
- Personality Profiles and State Aggressiveness in Finnish Alcoholic, Violent Offenders, Fire Setters, and Healthy VolunteersArchives of General Psychiatry, 1994
- Paternal and Maternal Genetic and Environmental Contributions to Cerebrospinal Fluid MonoamineMetabolites in Rhesus Monkeys (Macaca mulatta)Archives of General Psychiatry, 1993
- Cerebrospinal Fluid Monoamine and Adrenal Correlates of Aggression in Free-Ranging Rhesus MonkeysArchives of General Psychiatry, 1992
- Cerebrospinal Fluid Monoamine Metabolites, Aggression, and Impulsivity in Disruptive Behavior Disorders of Children and AdolescentsArchives of General Psychiatry, 1990
- Clinical Importance of Age at Onset in Type 1 and Type 2 Primary AlcoholicsArchives of General Psychiatry, 1990
- Inheritance of Alcohol AbuseArchives of General Psychiatry, 1981