In Vitro Susceptibility of Methicillin-resistant Staphylococcus aureus to Sulfamethoxazole and Trimethoprim

Abstract

Methicillin-resistant strains of Staphylococcus aureus were resistant to sulfamethoxazole. Only one of 47 strains was resistant to 1 µg/ml of trimethoprim, but all were susceptible to the combination of 16 µg/ml of sulfamethoxazole with 1 µg/ml of trimethoprim. However, the clinical effectiveness of the combination in the treatment of severe S. aureus infection remains to be evaluated.