Pulmonary oedema developed suddenly in two healthy male patients undergoing elective surgery, following the inadvertent injection of large doses of adrenaline. Both patients showed an immediate and dramatic response to treatment with intravenous chlorproma-zine. The pathophysiology of pulmonary oedema, and the pharmacology of its production by adrenaline overdose, as well as the effects of both adrenaline and chlorpromazine on the pulmonary and systemic circulation will be discussed