Intrasplenic Transplantation of Testes in Castrated Mice

Abstract

Thirty-two successful testicular homotransplants were recovered from 40 castrated o and o mice of the A strain bearing the intrasplenic transplants for a period ranging from 23-275 days. The testicular transplants showed the general histologic features of cryptorchid testes, although spermatids and sperm heads were noted in one case after 243 days of transplantation. The present material give no indication of tumor development in the intrasplenic testicular transplants. The exptl. data suggested that the endogenous androgen produced by the intrasplenic testicular transplant was inactivated when passing through the hepatic portal system.