Asymmetric Synthesis of AntiN-Boc-α-Hydrazino-β-Hydroxyesters from β-Ketoesters by Sequential Catalytic Hydrogenation and Electrophilic Amination

Abstract

Enantiomerically pure anti N-Boc-α-hydrazino-β-hydroxyesters were obtained from the corresponding β-ketoesters by hydrogenation with chiral Ruthenium catalysts and electrophilic amination of the β-hydroxyester with di-tert-butylazodicarboxylate (DBAD).