Specificity in the Factor VIII Response to Vasopressin Infusion in Man

Abstract

Structural requirements of the systemic factor VIII response to i.v. vasopressin in man were investigated using vasopressin analogs. With the analogs available the receptor specificity of this phenomenon could not be distinguished from those associated with the previously described plasminogen activator release or antidiuretic effects of this hormone. Further studies using 1-desamino-[8-D-arginine]vasopressin showed a dose-related release of procoagulant and antigenic components of the factor VIII complex. The newly released factor VIII could not be distinguished from circulating factor VIII on the basis of molecular size, electrophoretic mobility or in vitro stability despite apparent differences in the duration of response of the procoagulant and antigenic components in vivo.