High‐dose intravenous immunoglobulins in the treatment of demyelinating neuropathy associated with monoclonal gammopathy
- 1 February 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 40 (2), 212
- https://doi.org/10.1212/wnl.40.2.212
Abstract
We treated 2 patients with IgM monoclonal paraproteinemic demyelinating peripheral neuropathy (PPN) with monthly intravenous human immunoglobulin. Both patients had a steadily progressive course in spite of steroid and other immunosuppressive therapy for 3 years before starting the immunoglobulin therapy. Both that a rapid clinical improvement noticeable 5 to 10 days after the 1st immunoglobulin infusion lasting on the average of 3 to 6 weeks. Retreatment caused improvement after each consecutive infusion. There were no significant adverse side effects. High-dose IV human immunoglobulin can be a useful therapy in the treatment of PPN and warrants a large-scale controlled therapeutic trial.This publication has 2 references indexed in Scilit:
- High‐dose intravenous human immuno‐globulin in chronic inflammatory demyelinating polyneuropathyNeurology, 1989
- Specificity of human IgM monoclonal antibodies from patients with peripheral neuropathyJournal of Neuroimmunology, 1986