Virulence attenuation in Salmonella enterica rcsC mutants with constitutive activation of the Rcs system
- 1 February 2005
- journal article
- Published by Microbiology Society in Microbiology
- Vol. 151 (2), 579-588
- https://doi.org/10.1099/mic.0.27520-0
Abstract
Mutations in rcsC that result in constitutive colanic acid capsule synthesis were obtained in Salmonella enterica serovar Typhimurium. Most rcsC alleles were dominant; however, recessive rcsC alleles were also found, in agreement with the postulated double role (positive and negative) of RcsC on the activation of the RcsB/C phosphorelay system. Salmonella rcsC mutants with constitutive activation of the Rcs system are severely attenuated for virulence in BALB/c mice and their degree of attenuation correlates with the level of Rcs activation. Partial relief of attenuation by a gmm mutation indicates that capsule overproduction is one of the factors leading to avirulence in constitutively activated rcsC mutants.Keywords
This publication has 63 references indexed in Scilit:
- Swimming Motility, a Virulence Trait of Ralstonia solanacearum, Is Regulated by FlhDC and the Plant Host EnvironmentMolecular Plant-Microbe Interactions®, 2004
- SWISS-MODEL: an automated protein homology-modeling serverNucleic Acids Research, 2003
- Null mutations in the essential geneyrfF(mucM) are not lethal inrcsB,yojNorrcsCstrains ofSalmonella entericaserovar TyphimuriumFEMS Microbiology Letters, 2003
- Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence ofSalmonella entericaSerovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf EnterocolitisInfection and Immunity, 2001
- Role of theftsA1ppromoter in the resistance of mucoid mutants ofSalmonella entericato mecillinam: characterization of a new type of mucoid mutantFEMS Microbiology Letters, 2001
- Functions of the subunits in the FlhD 2 C 2 transcriptional master regulator of bacterial flagellum biogenesis and swarming 1 1Edited by I. B. HollandJournal of Molecular Biology, 2000
- NMR structure of activated CheYJournal of Molecular Biology, 2000
- Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two‐component system rcsC–rcsBMolecular Microbiology, 1999
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modelingElectrophoresis, 1997
- Magnesium Binding to the Bacterial Chemotaxis Protein CheY Results in Large Conformational Changes Involving its Functional SurfaceJournal of Molecular Biology, 1994