In enumerating the factors concerned in edema, one has come to recognize (though not always to explain) a number of conditions most commonly associated with the phenomenon, such as alterations in chemical and mineral balance, metabolic disturbances within the tissues, changes in colloidal state of dispersion, quantitative and qualitative changes in serum proteins, or endocrine dysfunction, and is able at times to deal empirically with the conditions and to obtain satisfactory results. Occasionally, however, one encounters situations entirely unique in so far as these recognized factors are concerned. It is the purpose of this paper to present two cases of generalized massive edema occurring only at the menstrual periods. As originally presented, the theme of the paper was edema, but the neurologic and gynecologic phases so overwhelmed the picture, and the internists had so little to contribute, that its appearance in this section is not unnatural. The first case has