The Differential Effect of Acetylsalicylic Acid on in vitro Aggregation of Platelets from Normal, Asthmatic and Aspirin-Sensitive Subjects

Abstract

In vitro studies of the effect of acetylsalicylic acid on the collagen-induced aggregation of human platelets are reported. It was found that collagen-induced platelet aggregation was significantly more sensitive to inhibition by aspirin in asthmatics than normal individuals. No significant difference was found between aspirin-hypersensitive and non-aspirin-hypersensitive asthmatics. The possible relationship of these findings to the β-adrenergic theory of asthma is discussed.