The Estimation of Local Brain Temperature by in Vivo1H Magnetic Resonance Spectroscopy
- 1 June 1995
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 33 (6), 862-867
- https://doi.org/10.1002/mrm.1910330620
Abstract
Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (θH2O-Naa) in piglet brain depended linearly on temperature from 30° to 40°C: temperature was 286.9–94.0 θH2O-Naa ° C. Thalamic temperature in six normal infants was 38.1° ± 0.4° C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.Keywords
This publication has 19 references indexed in Scilit:
- Internal temperature calibration for 1H NMR spectroscopy studies of blood plasma and other biofluidsNMR in Biomedicine, 1994
- MR temperature mapping of focused ultrasound surgeryMagnetic Resonance in Medicine, 1994
- The effect of temperature on MR relaxation times and signal intensities for human tissuesMagnetic Resonance Materials in Physics, Biology and Medicine, 1993
- A 1H‐NMR method for determining temperature in cell culture perfusion systemsMagnetic Resonance in Medicine, 1993
- A reappraisal of the absolute concentrations of phosphorylated metabolites in the human neonatal cerebral cortex obtained by fitting Lorentzian curves to the 31P NMR spectrumJournal of Magnetic Resonance (1969), 1991
- N-acetylaspartate as an intrinsic thermometer for 1H NMR of brain slicesJournal of Magnetic Resonance (1969), 1985
- Solvent suppression in fourier transform nuclear magnetic resonanceJournal of Magnetic Resonance (1969), 1983
- Observation of 1H NMR signals with receiver coils tuned for other nuclidesJournal of Magnetic Resonance (1969), 1981
- Suppression of artifacts in two-dimensional J spectroscopyJournal of Magnetic Resonance (1969), 1977
- Proton Magnetic Resonance Chemical Shift of Free (Gaseous) and Associated (Liquid) Hydride MoleculesThe Journal of Chemical Physics, 1958