Fatty Livers in Vitamin B6 Deficient Rats

Abstract

A study was made of the lipid content of livers of rats deficient invitamin B₆, as compared with normal animals and with deficient animals which had been given choline. The results show a significantly heavier liver containing a higher percentage of total fatty acids in the deficient animals. The addition of choline remedied the condition to a large extent, but even massive doses failed to bring the liver weight and total fatty acid content quite to normal. Storage of the lipid extracts for a period of about 3 months resulted in losses in both total fatty acids and phospholipid fatty acids, no change in total cholesterol values and a definite drop in all iodine numbers.