Modification of Ribosomes in Cryptopleurine-Resistant Mutants of Yeast
- 1 November 1973
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 116 (2), 818-822
- https://doi.org/10.1128/jb.116.2.818-822.1973
Abstract
Cryptopleurine-resistant mutants of Saccharomyces cerevisiae were isolated. A single, recessive nuclear gene, very closely linked to the mating locus (2.1 centimorgans), is responsible for resistance. Ribosomes from the mutants were found to be resistant to cryptopleurine when analyzed by poly(U)-directed polyphenylalanine synthesis. Analysis of the distribution of ribosomes between monosomes and polysomes in sensitive cells exposed to cryptopleurine suggests that some step is inhibited during the elongation phase of protein synthesis.Keywords
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