Confirmation of Presence of a Gastric Secretory Depressant in Gastric Juice of Humans

Abstract

The observation of Brunschwig and co-workers that the intraven. injn. of alcoholic precipitates of achlorhydric gastric juice from patients with pernicious anemia depresses gastric secretion in dogs has been confirmed. It was effective in inhibiting secretion provoked by histamine. The gastric secretory inhibitor was found in high concn. in achlorhydric gastric juice of persons without other demonstrable abnormalities in the gastro-intestinal tract or disease of the hemopoietic system. The gastric secretory inhibitor was absent or present in lower concns. in gastric juice from normal individuals.