The characterization and pathological significance of gastric campylobacter-like organisms in the ferret: a model for chronic gastritis?

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Abstract
SUMMARY: Gastric campylobacter-like organisms (CLO) were isolated from gastric tissues removed at sacrifice from 17 mature ferrets; all animals were colonized, but no macroscopic mucosal lesions or histological features of chronic gastritis were seen. The isolates resembledCampylobacter pyloriin many cultural and biochemical characteristics, and produced substantial urease activity, but there were sufficient differences fromC. pylorito suggest that ferret gastric CLO represents a separate species. Comparison of humanC. pyloriand ferret gastric CLO may help to clucidate the pathogenicity of the former in patients with gastritis, and the ferret may serve as a useful animal model for the study ofC. pyloriinfection.