Increased Reduced Glutathione and Glutathione S-Transferase Activity in Chronic Cephaloridine Nephrotoxicity Studies in the Rat
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 13 (2-3), 209-219
- https://doi.org/10.3109/01480549009018121
Abstract
The effect of repeated cephaloridine treatment on renal glutathione and related enzymes has been investigated in young adult male and female Sprague-Dawley rats. Animals were given intraperitoneally daily doses of either 750 mg/kg for two weeks or 500 or 750 mg/kg for three months. Measurement of blood and urinary parameters (electrolytes, urea, creatinine) did not reveal any renal function impairment and histological examination confirmed the absence of renal damage. By contrast, an increase in reduced glutathione (2 to 3-fold) and glutathione S-transferase activity (1.5 to 2-fold) was observed. These results are consistent with the development of an adaptative phenomenon to cehaloridine subchronic treatment in the rat, leading to a tolerance to high repeated doses.This publication has 18 references indexed in Scilit:
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