Effects of sodium salicylate on plasma insulin concentration and fatty acid turnover in dogs

Abstract

The effects of i.v. sodium salicylate administration on plasma concentrations of insulin, free fatty acids (FFA) and glucose were studied in intact, anesthetized dogs both during basal and isoprenaline stimulated lipolysis. In both situations sodium salicylate reduced plasma insulin concentrations. The reduction was associated with decreased plasma FFA concentrations and FFA turnover rate, while plasma glucose concentrations remained unaltered. The reduced plasma insulin concentrations effected by sodium salicylate is most likely secondary to the concomitant fall in plasma FFA concentrations due to inhibition of FFA mobilization from adipose tissue. New interest in the mode of action of salicylates has been created by recent findings that acetylsalicylic acid (ASA) might reduce the incidence of acute myocardial infarction.