Right ventricular diastolic pressure-volume relations and regional dimensions during acute alterations in loading conditions.
- 1 June 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 77 (6), 1276-1282
- https://doi.org/10.1161/01.cir.77.6.1276
Abstract
Acute pharmacologically mediated parallel shifts in the left ventricular diastolic pressure-volume relation may be due to the restraining effect of the pericardium and/or leftward displacement of the interventricular septum. The existence and cause of this phenomenon in the right ventricle has not been studied in animals or in man. Accordingly, we altered right ventricular pressure with intravenous phenylephrine (0.2 to 0.3 mg) and nitroprusside (0.5 to 1.5 micrograms/kg/min) to achieve three disparate peak right ventricular pressures in nine normal subjects after partial autonomic blockade with atropine (1 mg) and propranolol (0.15 mg/kg). Simultaneous high-fidelity right ventricular pressures and biplane cineventriculographic volumes were acquired during the three resultant loading conditions. Right atrial pacing maintained heart rate constant at each pressure level. Peak right ventricular systolic pressure (23 +/- 3 vs 31 +/- 9 vs 45 +/- 6 mm Hg, all p less than .01) and right ventricular end-diastolic pressure (4 +/- 2 vs 8 +/- 4 vs 11 +/- 3 mm Hg, all p less than .01) were significantly different at low, medium, and high loading conditions, respectively. Right ventricular diastolic pressure-volume relations were, in parallel, shifted upward with altered loading in each patient. This was manifest by an unchanged dynamic chamber stiffness constant and a significant increase in the diastolic pressure volume y intercept at each load (1.98 +/- 2.21 vs 5.33 +/- 5.39 vs 8.51 +/- 3.99 mm Hg, p less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)This publication has 8 references indexed in Scilit:
- Quantification of effect of pericardium on LV diastolic PV relation in dogsAmerican Journal of Physiology-Heart and Circulatory Physiology, 1987
- Pericardial influences on ventricular filling in the conscious dog. An analysis based on pericardial pressure.Circulation Research, 1984
- Pericardial modulation of right and left ventricular diastolic interaction.Circulation Research, 1981
- The pericardium substantially affects the left ventricular diastolic pressure-volume relationship in the dog.Circulation Research, 1978
- Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations.JCI Insight, 1977
- Left ventricular effects on right ventricular developed pressureJournal of Applied Physiology, 1976
- Haemodynamic effects of angiographic contrast material in man. A beat-by-beat analysis.Heart, 1972
- Dependence of ventricular distensibility on filling of the opposite ventricleAmerican Journal of Physiology-Legacy Content, 1967