Effects of Maternal Protein Restriction on the Kidney of the Newborn Young of Rats
- 1 February 1968
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 94 (2), 111-116
- https://doi.org/10.1093/jn/94.2.111
Abstract
The effect of maternal protein restriction on the kidney of the young rat was studied. Kidneys were taken from newborn young of rats fed semipurified diets containing 24% or 6% unsupplemented casein as the sole source of protein throughout pregnancy. There are definite morphological and histochemical differences between kidneys from the animals in the control and protein-deficient groups. Kidneys from the protein-restricted animals have fewer and less well-differentiated glomeruli, a greater proportion of connective tissue, and relatively fewer collecting tubules. PAS-stained sections indicate that proximal convoluted tubules are shorter and have fewer convolutions. Acid and alkaline phosphatase activities were reduced in kidneys of protein-deficient young, but no differences were found in the activities of ATPase, nonspecific esterase, or leucine aminopeptidase. Some changes also resemble those reported in kidneys of protein-deficient weanling rats. It is suggested that maternal protein restriction results in both immaturity in development in the kidneys of the young and in pathological changes symptomatic of protein deficiency.Keywords
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