Attempt to Stimulate Lymphatic Gland Changes of Fowl Typhoid With Adrenal Cortex Extract.

Abstract

Daily intramuscular injections of ACE for 6 days in amounts of 0.25 to 3 ml caused a significant reduction in weight of the thymus and the bursa of Fabricus. Two ml daily were adequate to cause both the weight loss and histological changes occurring in the bursa of Fabricius from chickens with fowl typhoid. Other significant changes observed for the groups given 1, 2, and 3 ml daily included decrease in body weight, increase in relative pituitary weight, reduction in adrenal weight (less cortical tissue), and increase in liver weight which bore a linear relationship with the level of ACE administration.