N,N‘-Di-tert-butoxycarbonyl-1H- benzotriazole-1-carboxamidine Derivatives Are Highly Reactive Guanidinylating Reagents
- 1 November 2001
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (24), 3859-3861
- https://doi.org/10.1021/ol010191q
Abstract
By enhancing the leaving group character of benzotriazole via electron-withdrawing substituents such as the 5-chloro or 6-nitro derivatives with the related N,N‘-di-tert-butoxycarbonyl-1H-benzotriazole-1-carboxamidines, highly efficient reagents are obtained for conversion of primary and secondary amines in solution and in solid phase to diprotected guanidines.Keywords
This publication has 6 references indexed in Scilit:
- Urethane protected derivatives of 1-guanylpyrazole for the mild and efficient preparation of guanidinesTetrahedron Letters, 1993
- 5 Amidines and Guanidines in Medicinal ChemistryProgress in Medicinal Chemistry, 1993
- A facile preparation of Fmoc-Argω,ω′(Boc)2 -OH and Z-Argω,ω′ (Boc)2 -OH, new arginine derivatives for peptide synthesis.Tetrahedron Letters, 1992
- Synthesis of optically pure Cα‐methyl‐arginineInternational Journal of Peptide and Protein Research, 1992
- 1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesisThe Journal of Organic Chemistry, 1992
- Ueber AzimidoleEuropean Journal of Organic Chemistry, 1900