Enantioselective hydrogenation of a cyclic imidoketone over chirally modified Pt/Al2O3

1 January 1998

journal article
research article
Published by Royal Society of Chemistry (RSC) in Chemical Communications

No. 13,p. 1377-1378
https://doi.org/10.1039/a801760c

Abstract

1-Ethyl-4,4-dimethylpyrrolidine-2,3,5-trione 1 has been synthesized, and hydrogenated with 91% ee to (R)-1-ethyl-3-hydroxy-4,4-dimethylpyrrolidine-2,5-dione (2) using a 5 mass% Pt/Al₂O₃ catalyst modified by cinchonidine

Keywords

CYCLIC IMIDOKETONE
ENANTIOSELECTIVE HYDROGENATION
PT/AL2O3 CATALYST
CHIRALLY MODIFIED
CATALYST MODIFIED
MODIFIED PT/AL2O3
DIONE
TRIONE

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