Direct Measurement of the Transport Properties of a Single DNA Molecule
- 18 September 1995
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 75 (12), 2436-2439
- https://doi.org/10.1103/physrevlett.75.2436
Abstract
A fluorescently labeled DNA molecule is end tethered to a small magnetic bead and pulled by a calibrated magnetic force through a solution of unlabeled DNA molecules to monitor the transport coefficients of the chain. From the force velocity diagram , we report the first direct measurement of the friction coefficient of a single DNA molecule. is found to be highly velocity dependent due to sharp conformational transitions for increasing velocities in agreement with a recent model by Ajdari et al. [Physica (Amsterdam) 204A, 17 (1994)].
Keywords
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