Corticosteroid Responses to Milieu Therapy of Chronic Schizophrenics
- 1 September 1966
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 15 (3), 310-319
- https://doi.org/10.1001/archpsyc.1966.01730150086013
Abstract
OVER the past two decades, it has been well established in both animals and man that emotional distress can stimulate adrenal cortical activity through neuroendocrine pathways. In man, however, emotional distress is regarded as being closely regulated by ego defenses (in a manner perhaps analogous to a buffer system). It appears useful, then, to study both the dimensions of affect state and ego defensive functions as a system, in psychoendocrine investigations in man. This paper will report on corticosteroid excretion in four chronic schizophrenic men during a year's course of intensive milieu therapy. Changes in affect state and in corticosteroid excretion will be related to alterations in the psychosocial equilibrium maintained by these chronic patients. The present study grows out of previous work by Sachar et al1,3,4 which described changes in corticosteroid excretion in acutely schizophrenic men as they moved through clinical phases in theirThis publication has 5 references indexed in Scilit:
- Corticosteroid Excretion in Normal Young Adults Living Under “Basal” ConditionsPsychosomatic Medicine, 1965
- Study of a Patient With 48-Hour Manic-Depressive CyclesArchives of General Psychiatry, 1965
- Steroid Excretion in Depressive DisordersArchives of General Psychiatry, 1964
- Psychoendocrine Aspects of Acute Schizophrenic ReactionsPsychosomatic Medicine, 1963
- CHEMICAL METHOD FOR THE DETERMINATION OF 17-HYDROXYCORTICOSTEROIDS AND 17-KETOSTEROIDS IN URINE FOLLOWING HYDROLYSIS WITH β-GLUCURONIDASE*Journal of Clinical Endocrinology & Metabolism, 1953