STUDIES ON THE REGULATION OF GASTRIC ACIDITY

Abstract

0.024-0.173 N HC1 does not inhibit the secretion of acid in fundic pouches or in the whole stomach. The same is true for HNO3 and H2SO4 alone or in combination with NaCl. When these HC1 solutions are placed in fundic pouches there is no increase in the amount of neutral chloride secreted by the pouch. The amount of neutral chloride in fundic secretion is very small and does not show the inverse relationship to the acid chloride that is found in the intact stomach. The chloride concentration of fundic secretion averaged 578 mgm. per 100 cc. This is approximately 0.163 [image] HC1. The concentration of HC1 secreted by fundic pouches is not altered by placing HC1 up to 0.173 [image] in the pouch. The chloride conc. of the combined secretions (fundic, pyloric and regurgitated duodenal contents) found in the intact stomach is lower than that of pure fundic secretion and the lowering is proportional to the amount of bile present in the gastric sample. When increasing strengths of HC1 and H2SO4 are placed in the stomach there is a progressive increase in the emptying time which is strictly proportional to the strength of acid introduced.