Mechanism of ribosome frameshifting during translation of the genetic code
- 1 March 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 302 (5907), 389-393
- https://doi.org/10.1038/302389a0
Abstract
Some frameshift mutations are strongly suppressed by limitation for particular aminoacyl-tRNA species. Ribosome frameshifting at a specific tryptophan codon during Trp-tRNA limitation accounts for suppression of a group of downstream frameshift alleles in the rIIB gene of bacteriophage T4. Genetic and physiological observations strongly suggest that ribosome frameshifting at this position depends on the binding of a noncognate (Leu) tRNA.Keywords
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