Metabolite inhibition of nitroglycerin metabolism in sheep tissue homogenates
- 1 November 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (11), 807-809
- https://doi.org/10.1111/j.2042-7158.1985.tb04972.x
Abstract
The metabolism of nitroglycerin in sheep tissue homogenates has been examined using tritiated nitroglycerin and a HPLC separation procedure. Nitroglycerin was metabolized by liver, lung, muscle, arterial and venous tissue to its dinitrometabolites and subsequently to mononitroglycerin. Addition of the dinitrometabolites substantially inhibited the degradation of nitroglycerin in all tissue homogenates.This publication has 12 references indexed in Scilit:
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