Cannabinoids and neuroinflammation
- 1 March 2004
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 141 (5), 775-785
- https://doi.org/10.1038/sj.bjp.0705667
Abstract
Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. Our aim is to identify immune functions modulated by cannabinoids that could account for their anti-inflammatory effects in these animal models.Keywords
This publication has 175 references indexed in Scilit:
- Autocrine and Paracrine Regulation of Lymphocyte CB2 Receptor Expression by TGF-βBiochemical and Biophysical Research Communications, 2002
- Changes in cannabinoid CB1 receptors in striatal and cortical regions of rats with experimental allergic encephalomyelitis, an animal model of multiple sclerosisSynapse, 2001
- Cardiovascular Effects of 2-Arachidonoyl Glycerol in Anesthetized MiceHypertension, 2000
- Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of AdenylylcyclaseJournal of Medicinal Chemistry, 1997
- Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptorsLife Sciences, 1997
- Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesisLife Sciences, 1997
- Inhibition of macrophage nitric oxide production by tetrahydrocannabinol in vivo and in vitroInternational Journal of Immunopharmacology, 1996
- Characterization and distribution of binding sites for [3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brainLife Sciences, 1996
- The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamideFEBS Letters, 1995
- Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats.Stroke, 1994