Laron Dwarfism and Mutations of the Growth Hormone–Receptor Gene
- 12 October 1989
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 321 (15), 989-995
- https://doi.org/10.1056/nejm198910123211501
Abstract
Laron dwarfism is associated with resistance to growth hormone (GH). To investigate its genetic basis, we used genetic linkage to test whether the disorder results from a defect in the gene for the human GH receptor. Denaturing gradient gel electrophoresis and sequencing of specific GH-receptor-gene fragments allowed us to characterize specific intragenic DNA markers in 35 control subjects of Mediterranean descent, for use in linkage studies.This publication has 28 references indexed in Scilit:
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