Neural cell adhesion molecule (NCAM) and prealbumin in cerebrospinal fluid from depressed patients
- 1 October 1988
- journal article
- review article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 78 (S345), 29-37
- https://doi.org/10.1111/j.1600-0447.1988.tb08565.x
Abstract
The size of the soluble form of the human cerebrospinal fluid (CSF) neural cell adhesion molecule, NCAM-sol, was by gel permeation chromatography estimated to 160-250 kDa. Within the CSF the concentration of NCAM-sol was found about 15-25% increased in lumbar fluid and 25% increased in ventricular fluid, both compared to cisternal fluid. Whereas prealbumin was found evenly distributed in CSF, albumin was relatively enriched in lumbar fluid. The concentrations of NCAM-sol and prealbumin were measured in lumbar CSF from psychiatric patients. Prealbumin was increased 7.2% and NCAM-sol was decreased 15.1% in depressed patients. The changes were partially normalized during recovery from the depression. The findings can be explained by hypothesizing that endogenous depression is associated with an increased choroid plexus activity and CSF production.Keywords
This publication has 55 references indexed in Scilit:
- NCAM: the molecule and its geneticsTrends in Genetics, 1986
- Synthesis of transthyretin (pre-albumin) mRNA in choroid plexus epithelial cells, localized by in situ hybridization in rat brain.Journal of Histochemistry & Cytochemistry, 1986
- Differential contributions of Ng-CAM and N-CAM to cell adhesion in different neural regions.The Journal of cell biology, 1986
- Biosynthesis of the neural cell adhesion molecule: characterization of polypeptide C.The Journal of cell biology, 1985
- Increased synaptic markers in hippocampus of depressed patientsJournal of Neural Transmission, 1985
- Immunocytochemical demonstration of the ‘neuronal membrane marker’ the D2-glycoprotein in human embryosNeuroscience Letters, 1983
- The nervous system specific protein D2 is involved in adhesion among neurites from cultured rat gangliaFEBS Letters, 1980
- Biogenic amine hypothesis of affective disordersLife Sciences, 1979
- Hormones, Electrolytes, and Cerebrospinal Fluid Proteins in Manic-Melancholic PatientsNeuropsychobiology, 1978
- Charge shift electrophoresis of synaptosomal membrane antigensFEBS Letters, 1977