Ligand-induced conformational switching and allosteric effects in macrocyclic porphyrin dimers

Abstract

Macrocyclic porphyrin dimers linked by biphenyl or pyromellitimide bridges show major conformational changes on protonation or on binding a single 1,4-diazabicyclo[2.2.2]octane (DABCO) molecule within the cavity; the binding of a second DABCO molecule leads to a further conformational switch.