INHIBITION OF THE ACETYLCHOLINE RECEPTOR BY HISTRIONICOTOXIN
Open Access
- 1 April 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 68 (4), 611-615
- https://doi.org/10.1111/j.1476-5381.1980.tb10851.x
Abstract
1 The action of C5-decahydrohistrionicotoxin (C5-HTX) has been investigated on the extrajunctional acetylcholine (ACh) receptors of denervated rat muscle. 2 C5-HTX causes both a rapid and slow reduction in amplitude of iontophoretic ACh potentials evoked at all frequencies from the extrajunctional receptors. 3 C5-HTX also causes a time-dependent inhibition of the iontophoretic potentials evoked at frequencies greater than 0.02 Hz. This inhibition was observed either alone or superimposed upon desensitization, and may be caused by a similar mechanism to desensitization.Keywords
This publication has 10 references indexed in Scilit:
- DESENSITIZATION OF THE ACETYLCHOLINE RECEPTOR OF DENERVATED RAT SOLEUS MUSCLE AND THE EFFECT OF CALCIUMBritish Journal of Pharmacology, 1980
- Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.Proceedings of the National Academy of Sciences, 1978
- Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin.Proceedings of the National Academy of Sciences, 1978
- Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.Proceedings of the National Academy of Sciences, 1977
- Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.Proceedings of the National Academy of Sciences, 1977
- BINDING OF PERHYDRO-HISTRIONICOTOXIN TO POSTSYNAPTIC MEMBRANE OF SKELETAL-MUSCLE IN RELATION TO ITS BLOCKADE OF ACETYLCHOLINE-INDUCED DEPOLARIZATION1977
- STUDIES ON EFFECT OF HISTRIONICOTOXIN ON MONOCELLULAR ELECTROPLAX FROM ELECTROPHORUS-ELECTRICUS AND ON BINDING OF [H-3]ACETYLCHOLINE TO MEMBRANE FRAGMENTS FROM TORPEDO-MARMORATA1976
- Effect of histrionicotoxin on the ionic conductance modulator of the cholinergic receptor: a quantitative analysis of the end-plate current.1974
- Acetylcholine Receptor and Ion Conductance Modulator Sites at the Murine Neuromuscular Junction: Evidence from Specific Toxin ReactionsProceedings of the National Academy of Sciences, 1973
- Junctional and extra-junctional acetylcholine receptors in skeletal muscle fibres.1960