Reproducibility of the Lethal Effect of Total-Body Irradiation in Mice

Abstract

Physical and biological prerequisites necessary for reproducibility of the lethal effect of total body irradiation are outlined. These measures are within the reach of every laboratory. With observation of these points reproducibility of a standard X ray dose over a period of several years is shown. It is demonstrated that at certain points of the dose response curve a high degree of accuracy in the biological discrimination of the lethal effects of various X-ray doses differing by [plus or minus] 2.5% can be accomplished.