Effect of Localized Brain Stem Lesions and Supradiaphragmatic Vagotomy on X-Irradiation Emesis in the Monkey
- 30 November 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 187 (3), 567-570
- https://doi.org/10.1152/ajplegacy.1956.187.3.567
Abstract
Bilateral ablation of area postrema by thermal coagulation resulted in loss of the normal early emetic response to total body x-irradiation in three monkeys (Macaca irus). Similar lesions in the lower descending vestibular nucleus with some damage to area postrema eliminated the vomiting reaction in one animal, but failed to do so in two others. Bilateral lesions in the dorsal sensory vagal nucleus without involvement of area postrema or other structures failed to inhibit vomiting to the standard dose of x-irradiation. In two other animals with similar lesions, but with extensive damage to area postrema or the nucleus of the tractus solitarius on one side, no vomiting occurred. Two animals with bilateral lesions in the superficial (ventricular) portion of the hypoglossal nuclei vomited during x-irradiation or in the usual interval following radiation. Supradiaphragmatic vagotomy resulted in complete inhibition of vomiting in five animals.Keywords
This publication has 7 references indexed in Scilit:
- Nerve fibers in the area postrema of cat, rabbit, guinea pig and ratThe Anatomical Record, 1955
- The Chemoreceptor Trigger Zone for Emesis in the MonkeyAmerican Journal of Physiology-Legacy Content, 1955
- Locus of Emetic Action Following Irradiation.Experimental Biology and Medicine, 1954
- A re‐evaluation of the cellular morphology of the area postrema in view of recent evidence for a chemoreceptor functionJournal of Comparative Neurology, 1954
- LOCUS OF EMETIC ACTION OF MORPHINE AND HYDERGINE IN DOGS1954
- Morphology of Emetic Chemoreceptor Trigger Zone in Cat Medulla OblongataExperimental Biology and Medicine, 1951
- FURTHER EXPERIMENTS IN AN ATTEMPT TO LOCATE THE SITE OF THE EMETIC ACTION OF THE DIGITALIS GLYCOSIDES1947